Vacuolar ATPase regulates ureteric bud branching morphogenesis during kidney development
Abstract
Disruption of normal kidney development results in a spectrum of congenital anomalies of the kidney and urinary tract (CAKUT), the major cause of end-stage kidney disease in children. We demonstrate that acidosis, kidney cell intracellular pH, and activity of V-ATPase pump are essential for normal kidney development.
Fields of Study & Subjects
Renal and related cancers
ATP Synthase and ATPases Research
Ion Transport and Channel Regulation
Publication details
- Journal / source
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Volume
- 330
- Issue
- 2
- Pages
- R166–R173
- Publication date
- 16 January 2026
- Language
- EN