Novel assessment of postprandial metabolism reveals sex-specific metabolic flexibility and lipid remodeling following volumetric muscle loss

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026 Open access

Read full text
Authors: Angela Bruzina, Braydon Crum, Leo A. Goodman, Yan Er Ng, Rachel L. Hawe, Jarrod A. Call, Sarah M. Greising
DOI: 10.1152/ajpregu.00259.2025
Cited by: 2
References: 73

Abstract

We developed a novel, freely ambulatory preclinical tool to assess dynamic postprandial metabolic flexibility. Using this tool, we identified sex differences in whole body energy expenditure and substrate utilization. The use of a single intramuscular glycerol injection model is not sufficient as a comparative model for evaluating chronic ectopic lipid accumulation and metabolic disruptions. In the context of volumetric muscle loss injury, disruptions in metabolic flexibility occur alongside alterations in lipid handling and ectopic lipid accumulation.

Fields of Study & Subjects

Exercise and Physiological Responses Adipose Tissue and Metabolism Muscle metabolism and nutrition

Publication details

Journal / source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
R243–R260
Publication date
14 January 2026
Language
EN