Nitric oxide synthase activation in nTS is essential to NMDA receptor dependent encoding of the cough reflex

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026 Open access

Read full text
Authors: David Farmer, Nanako Mori, Loren Saulsberry, Brendan J. Canning
DOI: 10.1152/ajpregu.00290.2025
Cited by: 2
References: 81

Abstract

Nitric oxide (NO) acts downstream from NMDA receptor activation to encode the cough reflex but without involvement of soluble guanylate cyclase. We propose that the enhancement of glutamatergic signaling by NO, perhaps through nitrosylation mechanisms, is an essential component of signal transduction at the synapses between cough receptor afferent nerves and their solitary tract nuclei (nTS) relay neurons.

Fields of Study & Subjects

Respiratory and Cough-Related Research Neuroscience of respiration and sleep Asthma and respiratory diseases

Publication details

Journal / source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
R396–R407
Publication date
18 February 2026
Language
EN