Serum endothelial monocyte-activating polypeptide-II response after 9 h of passive heat exposure: influence of age, diabetes, or hypertension

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026

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Authors: W. Shane Journeay, James J. McCormick, Kelli E. King, Joel M. Garrett, Fergus K. O’Connor, Kate P. Hutchins, Robert D. Meade, Glen Patrick Kenny
DOI: 10.1152/ajpregu.00307.2025
Cited by: 0
References: 33

Abstract

This study is the first to demonstrate that prolonged passive heat exposure (9 h at 40°C, 9% relative humidity) elicits differential EMAP-II cytokine responses across age and health status. Young adults exhibited significant increases in EMAP-II, whereas older adults without HTN or T2D showed a blunted response. In contrast, older adults with HTN and/or T2D displayed elevated baseline and postexposure EMAP-II, revealing disease-specific inflammatory responses linked to heat vulnerability.

Fields of Study & Subjects

Thermoregulation and physiological responses Heat shock proteins research Spaceflight effects on biology

Publication details

Journal / source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Volume
330
Issue
2
Pages
R119–R125
Publication date
9 January 2026
Language
EN