Diurnal and sex-specific renal responses to vasopressin receptor 2 agonism and antagonism in mice
Abstract
Desmopressin (dDAVP) is more potent during the active phase in mice, resulting in a greater plasma dilution and a potential risk for hyponatremia. This time-of-day difference likely reflects increased water intake during the active period, as well as diurnal changes in renal physiology, including higher glomerular filtration, a stronger medullary interstitial osmotic gradient, and increased AQP2 phosphorylation at S256 that together promote greater water retention.
Fields of Study & Subjects
Neuroendocrine regulation and behavior
Electrolyte and hormonal disorders
Ion Transport and Channel Regulation
Publication details
- Journal / source
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 6
- Pages
- F772–F782
- Publication date
- 14 May 2026
- Language
- EN