Vascular transcriptional and metabolic changes precede progressive intrarenal microvascular rarefaction in autosomal dominant polycystic kidney disease

American Journal of Physiology-Renal Physiology 2026 Open access

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Authors: Gizem Yilmaz, Santu Kumar Singha, Bansi Savaliya, Ahmed Abdelfattah, Walaa Elsekaily, Xiaohong Xu, Y. Zhang, Christian Hanna, Marie C. Hogan, Alejandro Chade, Alfonso Eirin, Maria Valentina Irazabal
DOI: 10.1152/ajprenal.00266.2025
Cited by: 1
References: 115

Abstract

We provide the first longitudinal and most comprehensive analysis of the intrarenal microvasculature in a slowly progressive model of autosomal dominant polycystic kidney disease (ADPKD) and integrate the findings with studies in a young cohort of individuals with ADPKD. We identified vasculature-related pathways that could be targeted for therapeutic interventions and contribute promising, noninvasive biomarkers in patients with ADPKD. Alterations of the intrarenal microcirculation may affect drug delivery; a better understanding of its longitudinal changes may aid in treatment management.

Fields of Study & Subjects

Genetic and Kidney Cyst Diseases Renal cell carcinoma treatment Pediatric Urology and Nephrology Studies

Publication details

Journal / source
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
F326–F345
Publication date
5 February 2026
Language
EN