Depletion of renal cortical collecting duct-secreted PCSK9 in early proteinuria prevents sustained nephrotic syndrome-related hypercholesterolemia

American Journal of Physiology-Renal Physiology 2026 Open access

Read full text
Authors: Eduardo Molina‐Jijón, Itzel Pamela Zavala-Guevara, Stéphanie Gambut, Tania Gomez-Sierra, Carmen Ávila-Casado, Camille Macé, Lionel C. Clément
DOI: 10.1152/ajprenal.00350.2025
Cited by: 1
References: 26

Abstract

The goal of this study was to investigate the biology of CCD-secreted PCSK9 and its role in MCD-associated hypercholesterolemia. PCSK9 expression was increased in the kidney, but reduced in the liver, suggesting that elevated circulating PCSK9 levels may originate from the kidney. Administration of anti-PCSK9 antibodies targeting circulating kidney-derived PCSK9 prevented the development of significant and sustained hypercholesterolemia in the PAN rat model of human MCD-associated nephrotic syndrome.

Fields of Study & Subjects

Renal Diseases and Glomerulopathies Lipoproteins and Cardiovascular Health Renal and Vascular Pathologies

Publication details

Journal / source
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Volume
330
Issue
6
Pages
F724–F734
Publication date
30 April 2026
Language
EN