Activation of farnesoid X receptor inhibits TMEM16A-mediated chloride secretion in renal collecting duct cells and retards renal cyst progression

American Journal of Physiology-Renal Physiology 2026

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Authors: Nipitpon Srimai, Kanlayanee Tonum, Sanya Sureram, Alisa Tubsuwan, Prasat Kittakoop, Sunhapas Soodvilai
DOI: 10.1152/ajprenal.00370.2025
Cited by: 0
References: 32

Abstract

Activation of farnesoid X receptor (FXR) downregulates TMEM16A-mediated Cl − secretion in renal collecting duct cells. FXR stimulation reduces cyst enlargement in Pkd1-deleted collecting duct cells and in PKD rats. The data support that FXR may be a candidate target for the treatment of autosomal dominant polycystic kidney disease.

Fields of Study & Subjects

Genetic and Kidney Cyst Diseases Ion Transport and Channel Regulation Cystic Fibrosis Research Advances

Publication details

Journal / source
American Journal of Physiology-Renal Physiology
Volume
330
Issue
4
Pages
F444–F455
Publication date
27 February 2026
Language
EN