Injury-induced paracrine effects on the podocyte’s transcriptome

American Journal of Physiology-Renal Physiology 2026 Open access

Read full text
Authors: Yuting Zeng, Robert Allen Schweickart, Jana Sharara, Joseph C. Maggiore, Carol J. Loretz, Neil A. Hukriede, Jeffrey W. Pippin, Ashleigh B. Theberge, Oliver Wessely, Stuart J. Shankland
DOI: 10.1152/ajprenal.00408.2025
Cited by: 1
References: 34

Abstract

From a clinical perspective, it is ideal if yet unknown common pathways could be therapeutically targeted in different forms of injury in diseases of podocytes, and if there were mitigation strategies to minimize further damage to yet unaffected podocytes. The results of the current studies showed that there are indeed common responses to different experimental forms of podocyte injury and identified common paracrine signaling from injured podocytes that adversely affects the neighboring healthy podocyte population.

Fields of Study & Subjects

Renal Diseases and Glomerulopathies Chronic Kidney Disease and Diabetes Genetic and Kidney Cyst Diseases

Publication details

Journal / source
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
F365–F378
Publication date
16 February 2026
Language
EN