Acute kidney injury biomarker responses in young and older female adults following mild hypohydration

American Journal of Physiology-Renal Physiology 2026 Open access

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Authors: Christin Domeier, Austin T. Robinson, Matthew C. Babcock, Joseph D. Vondrasek, Thomas G. Bissen, Colleen X. Muñoz, Kyle A. Smith, Joseph C. Watso
DOI: 10.1152/ajprenal.00414.2025
Cited by: 2
References: 63

Abstract

This is the first study to assess the effects of mild hypohydration on acute kidney injury biomarkers in young and older female adults. Mild hypohydration altered acute kidney injury biomarker concentrations in both age groups, with no observed age-related differences, contrasting with male studies that show an age-related decline. These findings highlight the need for targeted research on potential sex-related differences in kidney function decline with aging.

Fields of Study & Subjects

Thermoregulation and physiological responses Acute Kidney Injury Research Electrolyte and hormonal disorders

Publication details

Journal / source
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
F456–F466
Publication date
27 February 2026
Language
EN