Extracellular vesicle transcriptomes in human urine capture kidney adaptation to sodium intake
Abstract
The kidneys adapt to changes in Na + intake by regulating tubular Na + transport, and we investigated whether the RNA content of urinary EVs (uEV) reflects the physiological responses to dietary Na + intake in humans. Dietary Na + intake altered both transcript abundance and kidney-derived uEV levels, which correlated with renin, aldosterone, and blood pressure levels. Thus, uEV transcriptomics provide a noninvasive window for studying the molecular control of kidney Na + handling in humans.
Fields of Study & Subjects
Sodium Intake and Health
Ion Transport and Channel Regulation
Hormonal Regulation and Hypertension
Publication details
- Journal / source
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 4
- Pages
- F379–F388
- Publication date
- 19 February 2026
- Language
- EN