Reproducing human diabetic nephropathy in a novel obesity-driven animal model

American Journal of Physiology-Renal Physiology 2026

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Authors: Silvia Teixidó-Trujillo, Esteban Porrini, María Fernanda Toniolo, Sergio Luis Lima, Laura Díaz Martin, Rosa Rodríguez-Rodríguez, Luis Manuel Menéndez-Quintanal, Armando Torres-Ramírez, Cecilia Fumero, Ana Elena Rodríguez‐Rodríguez
DOI: 10.1152/ajprenal.00455.2025
Cited by: 0
References: 41

Abstract

We present a nongenotypic, obesity- and tacrolimus-induced rat model that recapitulates the chronic progression of human diabetic nephropathy. The model reproduces key early and advanced features, including hyperfiltration, glomerular filtration rate (GFR) decline, glomerular hypertrophy, mesangial expansion, nodular sclerotic lesions, and tubular-interstitial fibrosis. Its translational relevance and long-term progression provide a valuable platform for mechanistic studies and for evaluating potential therapeutic strategies.

Fields of Study & Subjects

Chronic Kidney Disease and Diabetes Renal Diseases and Glomerulopathies Acute Kidney Injury Research

Publication details

Journal / source
American Journal of Physiology-Renal Physiology
Volume
330
Issue
4
Pages
F433–F443
Publication date
27 February 2026
Language
EN