Therapeutic effects of imidazoline 2 receptor activation on lower urinary tract dysfunction in a mouse model of spinal cord injury

American Journal of Physiology-Renal Physiology 2026 Open access

Read full text
Authors: Mamoru Hashimoto, Sergei V. Karnup, Stephanie L. Daugherty, Kang Jun Cho, Kanako Matsuoka, Shingo Kimura, Tadanobu Chuyo Kamijo, Koichi Sugimoto, Nobutaka Shimizu, Hirotsugu Uemura, Kazutoshi Fujita, Jonathan M. Beckel
+1 more Naoki Yoshimura
DOI: 10.1152/ajprenal.00457.2025
Cited by: 1
References: 25

Abstract

This study shows that selective activation of the imidazoline-2 receptor improves both detrusor overactivity and detrusor-sphincter dyssynergia after spinal cord injury. Systemic and intrathecal administration of 2BFI produced coordinated actions in the spinal cord and lower urinary tract, including enhanced relaxation of the external urethral sphincter, reduced inflammation mediated by C-fiber afferents, and direct relaxation of bladder smooth muscle, indicating a promising therapeutic target.

Fields of Study & Subjects

Neuroscience of respiration and sleep Urinary Bladder and Prostate Research Neurotransmitter Receptor Influence on Behavior

Publication details

Journal / source
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Volume
330
Issue
5
Pages
F592–F600
Publication date
28 March 2026
Language
EN