Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats
Abstract
Although diurnal cycle influences respiratory motor plasticity elicited by acute intermittent hypoxia (AIH), it is unknown how endogenous circadian clock mechanisms contribute to time-of-day effects on plasticity. We report that knockdown of the circadian clock protein Bmal1 within respiratory motor neurons attenuates phrenic and ventilatory long-term facilitation in a manner dependent on diurnal phase. Thus, circadian biology is an important consideration for studies of respiratory motor plasticity.
Fields of Study & Subjects
Neuroscience of respiration and sleep
Chronic Obstructive Pulmonary Disease (COPD) Research
High Altitude and Hypoxia
Publication details
- Journal / source
- Function
- Publisher
- American Physiological Society
- Volume
- 7
- Issue
- 4
- Pages
- e0162026–e0162026
- Publication date
- 9 June 2026
- Language
- EN