Epigenetic modifications of VEGF, cerebral hypoxia, and impaired cerebrovascular autoregulation as early indicators for preterm brain injury

Function 2026 Open access

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Authors: Celina L. Brunsch, Daphne H. Klerk, Dorian Blommaert, Richelle G. Middel, Bineta E. Lahr, Annemiek M. Roescher, Torsten Plösch, Elisabeth M. W. Kooi
DOI: 10.1152/function.088.2025
Cited by: 0
References: 60

Abstract

Neurodevelopmental impairments after preterm birth remain prevalent. Preterm brain injury, such as intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), occurs due to immature vascularization and impaired cerebral blood flow. We explored epigenetic changes in the vascular endothelial growth factor A ( VEGFA) and cerebrovascular autoregulation as biomarkers for preterm brain injury. Preterm neonates

Fields of Study & Subjects

Neonatal and fetal brain pathology Infant Development and Preterm Care Cardiovascular Conditions and Treatments

Publication details

Journal / source
Function
Volume
7
Issue
2
Pages
e0882025–e0882025
Publication date
13 February 2026
Language
EN