Ventilatory inefficiency in obstructive lung disease reveals emergent PaCO2 equilibrium during exercise
Abstract
Despite very different levels of obstructive lung disease and ventilatory insufficiency, [Formula: see text] and [Formula: see text] display an inverse relationship with V̇e/V̇co 2 across exercise levels. Stratification by V̇e/V̇co 2 demonstrates that interindividual differences in V̇e/V̇co 2 were driven by changes in effective alveolar ventilation. These results support the view that [Formula: see text] stability is apparent during exercise. [Formula: see text] passively emerges from the interactions between a constrained respiratory plant at any ventilatory drive.
Fields of Study & Subjects
Chronic Obstructive Pulmonary Disease (COPD) Research
Respiratory Support and Mechanisms
Delphi Technique in Research
Publication details
- Journal / source
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Volume
- 140
- Issue
- 6
- Pages
- 1684–1696
- Publication date
- 23 April 2026
- Language
- EN