Muscle atrophy after ACL reconstruction involves molecular mechanisms beyond unloading

Journal of Applied Physiology 2026 Open access

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Authors: Alexander R. Keeble, Sara Gonzalez-Velez, Nicholas T. Thomas, Allison M. Owen, Austin V. Stone, Darren L. Johnson, Julián Candia, Luigi Ferrucci, Marco Narici, E Dupont-Versteegden, Brian Noehren, Martino V. Franchi
+1 more Chris S Fry
DOI: 10.1152/japplphysiol.00088.2026
Cited by: 2
References: 48

Abstract

Disuse is often suggested as a major driver of quadriceps pathology following anterior cruciate ligament reconstruction (ACLR). This study identifies shared and unique gene signatures that occur early with ACLR and unilateral lower limb suspension (ULLS), highlighting ACLR-specific responses that likely contribute to prolonged quadriceps atrophy and weakness.

Fields of Study & Subjects

Knee injuries and reconstruction techniques Muscle Physiology and Disorders Osteoarthritis Treatment and Mechanisms

Publication details

Journal / source
Journal of Applied Physiology
Publisher
American Physiological Society
Volume
140
Issue
4
Pages
1123–1130
Publication date
26 March 2026
Language
EN