Does excess exercise-induced cardiac activation at exercise onset independently generate increases in cardiovascular circuit flow?
Abstract
Whether increasing cardiac activation above normal can increase cardiovascular circuit blood flow above normal at exercise onset in humans remained unclear. We found that excess exercise-induced cardiac activation created a greater increase in cardiac output via greater heart rate increases. Furthermore, exercising leg perfusion also increased to a greater extent due to elevated arterial blood pressure created by greater cardiac output. In conclusion, increased cardiac activation can improve cardiovascular circuit flow responses at exercise onset.
Fields of Study & Subjects
Cardiovascular and exercise physiology
Thermoregulation and physiological responses
Cardiovascular Effects of Exercise
Publication details
- Journal / source
- Journal of Applied Physiology
- Volume
- 140
- Issue
- 3
- Pages
- 686–698
- Publication date
- 30 January 2026
- Language
- EN