Changes in pulmonary function and airway mechanics with increased serum osmolality

Journal of Applied Physiology 2026 Open access

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Authors: Elizabeth A. Gideon, Colin D. Hubbard, M. Jo Hite, Zachary J. Schlader, Joseph W. Duke, Troy James Cross
DOI: 10.1152/japplphysiol.00239.2025
Cited by: 0
References: 36

Abstract

Increased serum osmolality through hypertonic saline infusion leads to a decrease in forced vital capacity and forced expiratory volume in 1 s. This decline in pulmonary function is likely resultant from changes in airway structure and function based on changes in closing capacity and maximal flow-static recoil curves following hypertonic saline infusion.

Fields of Study & Subjects

Chronic Obstructive Pulmonary Disease (COPD) Research Asthma and respiratory diseases Respiratory and Cough-Related Research

Publication details

Journal / source
Journal of Applied Physiology
Volume
140
Issue
2
Pages
501–511
Publication date
14 January 2026
Language
EN