Intercellular contact is sufficient to drive fibroblast-to-myofibroblast transitions
Abstract
This study uncovers a novel mechanism of fibroblast-to-myofibroblast transition (FMT) driven by cell-cell contact. Myofibroblast-fibroblast contact elevates cytoskeletal tension in the fibroblast, which in turn drives transition via activation of the GqGPCR signaling pathway. This process occurs independently of exogenous biochemical cues or stiff matrices. Emphasizing the central role of cytoskeletal stress in FMT, these findings reveal a mechanoregulated pathway, opening potential new avenues to investigate myofibroblast persistence.
Fields of Study & Subjects
Cardiovascular Function and Risk Factors
Hemoglobin structure and function
Tissue Engineering and Regenerative Medicine
Publication details
- Journal / source
- Journal of Applied Physiology
- Volume
- 140
- Issue
- 6
- Pages
- 1592–1604
- Publication date
- 29 April 2026
- Language
- EN