Attenuated myogenic response and contractility in middle cerebral arteries after cardiac arrest: a randomized experimental rat study

Journal of Applied Physiology 2026 Open access

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Authors: Frederik Boe Hansen, Katrine D Brodersen, Niels Secher, Judit Prat‐Duran, Susie Mogensen, Ulf Simonsen, Asger Granfeldt
DOI: 10.1152/japplphysiol.00527.2025
Cited by: 0

Abstract

Cerebral autoregulation is impaired in the postcardiac arrest period, potentially altering cerebral blood flow and exacerbating neurological injury after resuscitation. To our knowledge, the current study is the first to demonstrate that cerebral arteries exhibit reduced myogenic response, tone, and contractility in an animal model following resuscitation from cardiac arrest. These alterations in vasoreactivity appear to result, at least in part, from decreased calcium sensitivity in cerebral vascular smooth muscle cells.

Fields of Study & Subjects

Cardiac Arrest and Resuscitation Traumatic Brain Injury and Neurovascular Disturbances Takotsubo Cardiomyopathy and Associated Phenomena

Publication details

Journal / source
Journal of Applied Physiology
Volume
140
Issue
3
Pages
710–721
Publication date
9 February 2026
Language
EN