Shaping smooth muscle forces: the role of preconditioning in urinary smooth muscle
Abstract
This study investigates how different preconditioning routines (passive cycling, no preconditioning, and free contraction) affect active and passive force generation in porcine urinary bladder smooth muscle. Using a subsequent standardized protocol, we show that the preconditioning choice influences both force magnitude and variability, with free contraction minimizing passive force variance and avoiding creep-induced lengthening. Our findings highlight the need for tailored preconditioning strategies to improve reproducibility in smooth muscle experiments and enhance biomechanical organ modeling.
Fields of Study & Subjects
Elasticity and Material Modeling
Tissue Engineering and Regenerative Medicine
Pelvic floor disorders treatments
Publication details
- Journal / source
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Volume
- 140
- Issue
- 4
- Pages
- 971–982
- Publication date
- 5 March 2026
- Language
- EN