Fluid balance, kidney function, and acute kidney injury risk in healthy men and women during simulated work-related heat stress

Journal of Applied Physiology 2026 Open access

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Authors: Jessica A. Freemas, Curtis S. Goss, Riley Ables, Tyler B. Baker, Georgie Bruinvels, Toby Mündel, Bruce J. Martin, Stephen J. Carter, Robert F. Chapman, Omkar Khandpekar, Roger S. Zoh, Zachary J. Schlader
DOI: 10.1152/japplphysiol.00822.2025
Cited by: 1
References: 73

Abstract

Although men are often thought to be at greater risk of dehydration during work-related heat stress due to lower fluid intake, the impact of biological sex on fluid balance remains unclear. This study shows that when cool fluids are available, men and women maintain similar fluid balance regardless of menstrual cycle phase, suggesting that sex does not influence dehydration risk during simulated work-related heat stress.

Fields of Study & Subjects

Thermoregulation and physiological responses Exercise and Physiological Responses Muscle metabolism and nutrition

Publication details

Journal / source
Journal of Applied Physiology
Publisher
American Physiological Society
Volume
140
Issue
5
Pages
1187–1202
Publication date
31 March 2026
Language
EN