A novel method to estimate discharge-independent inhibition durations of spinal and brainstem circuits in humans
Abstract
Direct recordings from human motoneurons are not feasible; therefore, synaptic inhibition must be estimated indirectly. Experiments on rat brain slices allow accurate prediction of inhibition duration, independent of motor unit discharge rate. Applying these predictions in human studies has revealed discharge rate-independent functional inhibitions across various brainstem and spinal circuits. This approach offers robust estimates of functional inhibition, with potential clinical applications for monitoring neurological disorders that affect neural circuits.
Fields of Study & Subjects
Transcranial Magnetic Stimulation Studies
Muscle activation and electromyography studies
Vestibular and auditory disorders
Publication details
- Journal / source
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Volume
- 140
- Issue
- 3
- Pages
- 639–651
- Publication date
- 30 January 2026
- Language
- EN