Acute effects of inhaled nitric oxide on inspiratory neural drive, dyspnea, and exercise endurance in symptomatic patients post-pulmonary embolism

Journal of Applied Physiology 2026

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Authors: Devin B. Phillips, Matthew D. James, Sandra Vincent, Reginald M. Smyth, Bridgett Chau, Christine A. Darko, Kathryn M. Milne, Sophie É. Collins, Christine L. D'Arsigny, Juan P de-Torres, Kerstin de Wit, Amer M. Johri
+2 more José Alberto Neder, Denis E. O'Donnell
DOI: 10.1152/japplphysiol.00916.2025
Cited by: 1
References: 58

Abstract

The current study confirmed that excessive inspiratory neural drive contributed to troublesome dyspnea and exercise intolerance in individuals with a history of pulmonary embolism and that these could be partially mitigated by acute selective pulmonary vasodilation via inhaled nitric oxide. This study increased our understanding of the complex mechanisms of exertional dyspnea in individuals post-PE with persistent abnormal physiological responses during CPET.

Fields of Study & Subjects

Chronic Obstructive Pulmonary Disease (COPD) Research Cardiovascular and exercise physiology Heart Rate Variability and Autonomic Control

Publication details

Journal / source
Journal of Applied Physiology
Publisher
American Physiological Society
Volume
140
Issue
4
Pages
872–884
Publication date
10 February 2026
Language
EN