Exercise FITT-V during pregnancy: dose-dependent reduction in infant cellular lipid content and whole body fat

Journal of Applied Physiology 2026 Open access

Read full text
Authors: Alex Claiborne, Filip Jevtovic, Ericka Marie Biagioni, Lindsey Rossa, Caitlyn Ollmann, Donghai Zheng, Cody Strom, Breanna Wisseman, Samantha M. McDonald, Edward R. Newton, Steven Mouro, James DeVente
+4 more George Kelley, Joseph A. Houmard, Nicholas T. Broskey, Linda E. May
DOI: 10.1152/japplphysiol.00939.2025
Cited by: 2
References: 28

Abstract

This study was the first to test how specific prenatal exercise dose, i.e., the FITT-V (frequency, intensity, time, type, volume) metrics, could influence the storage of triglycerides in infant adipogenic mesenchymal stem cells (MSCs). Prenatal exercise led to a reduction in infant whole body fat percentage (BF%), which was reflected by lower lipid storage in infant MSCs. Changes in lipid content were observed in offspring born to participants exercising beyond the minimum recommended weekly volume, 450 metabolic equivalent (MET)·min/wk.

Fields of Study & Subjects

Gestational Diabetes Research and Management Birth Development and Health Adipose Tissue and Metabolism

Publication details

Journal / source
Journal of Applied Physiology
Publisher
American Physiological Society
Volume
140
Issue
3
Pages
677–685
Publication date
10 February 2026
Language
EN