The near-infrared diffuse correlation spectroscopy muscle perfusion index in human calf muscle: accounting for changes in hemoconcentration

Journal of Applied Physiology 2026

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Authors: Miles F. Bartlett, K Austin Davis, Erin K. Englund, Hanli Liu, Michael D Nelson
DOI: 10.1152/japplphysiol.01054.2025
Cited by: 1
References: 32

Abstract

We compared changes in skeletal muscle blood flow estimated by NIRS-DCS against arterial spin-labeling MRI during ischemic reperfusion and exercise. NIRS-DCS blood flow index underestimated relative changes in muscle perfusion across all procedures unless the calculations were adjusted for changes in hemoconcentration and total heme content, which resulted in a muscle perfusion index (MPI) that was almost superimposed on ASL-MRI. These results demonstrate that NIRS-DCS MPI noninvasively quantifies changes in muscle perfusion in humans.

Fields of Study & Subjects

Optical Imaging and Spectroscopy Techniques Cardiovascular and exercise physiology Advanced MRI Techniques and Applications

Publication details

Journal / source
Journal of Applied Physiology
Publisher
American Physiological Society
Volume
140
Issue
5
Pages
1431–1441
Publication date
30 April 2026
Language
EN