Exogenous ketosis mitigates hypoxia-induced neural signaling alterations and cerebral oxygenation decline at rest in healthy males

Journal of Applied Physiology 2026 Open access

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Authors: Nathan Vermaerke, Siemon VERMEIREN, Domen Tominec, Wout Lauriks, Ruben Robberechts, Tadej Debevec, Dante Mantini, Chiel Poffé, Myrthe Stalmans
DOI: 10.1152/japplphysiol.01059.2025
Cited by: 2
References: 128

Abstract

This study is the first to demonstrate the effects of ketone ester ingestion on hypoxia-induced neural alterations. Moreover, it uniquely combines measurements of cerebral oxygenation, cognitive performance, and electroencephalography (EEG) across low-, high-, and all-out exercise intensities, as well as during rest. Potentially highlighting EEG as a valuable tool for monitoring fatigue and optimizing training strategies.

Fields of Study & Subjects

High Altitude and Hypoxia Diet and metabolism studies Neuroscience of respiration and sleep

Publication details

Journal / source
Journal of Applied Physiology
Publisher
American Physiological Society
Volume
140
Issue
4
Pages
1069–1084
Publication date
4 March 2026
Language
EN