Local apocynin improves acetylcholine- but not insulin-mediated vasodilation in the cutaneous microvasculature of women with a history of gestational diabetes
Abstract
Women who experienced gestational diabetes are at a high risk of developing cardiovascular disease and type 2 diabetes. This risk may be mediated, in part, by endothelial dysfunction after pregnancy. We demonstrate that NADPH oxidase inhibition with apocynin improves microvascular endothelial responses to acetylcholine but not to insulin in healthy women with a history of gestational diabetes. These findings suggest that NADPH oxidase contributes to microvascular endothelial dysfunction and chronic disease progression after gestational diabetes.
Fields of Study & Subjects
Nitric Oxide and Endothelin Effects
Gestational Diabetes Research and Management
Pregnancy and preeclampsia studies
Publication details
- Journal / source
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Volume
- 140
- Issue
- 4
- Pages
- 983–992
- Publication date
- 27 February 2026
- Language
- EN