Moderate hyperthermia impairs dynamic cerebral autoregulation but not its directional sensitivity

Journal of Applied Physiology 2026

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Authors: Mahmoudreza Taghizadeh, Marc‐Antoine Roy, Shahrzad Soleimani Dehnavi, Daniel Gagnon, Patrice Brassard
DOI: 10.1152/japplphysiol.01131.2025
Cited by: 3
References: 55

Abstract

Using a multimetric approach combining transfer function analysis with absolute and normalized directional sensitivity metrics, we show that moderate hyperthermia impairs dynamic cerebral autoregulation while preserving its directional sensitivity. Notably, asymmetry in the cerebral pressure-flow relationship was evident at both 0.05 and 0.10 Hz when using the normalized metric, despite heat-induced reductions in dynamic buffering. These findings suggest that distinct mechanisms govern the dynamic and directional components of cerebral autoregulation.

Fields of Study & Subjects

Traumatic Brain Injury and Neurovascular Disturbances Cerebrospinal fluid and hydrocephalus Cardiac Arrest and Resuscitation

Publication details

Journal / source
Journal of Applied Physiology
Publisher
American Physiological Society
Volume
140
Issue
4
Pages
911–926
Publication date
19 February 2026
Language
EN