Limitations in dosing of electrical nerve stimulation: assessment with compound potential measurements

Journal of Applied Physiology 2026 Open access

Read full text
Authors: Alwin So, Isabella Pejkovic, İsmaıl Devecıoğlu, Felix P. Aplin, Ingvars Birznieks, Richard Martin Vickery
DOI: 10.1152/japplphysiol.01172.2025
Cited by: 1
References: 68

Abstract

This study contributes to understanding the effects of electrical stimulation on nerve responsiveness via compound action potential (CAP) measurements. Contrary to existing assumptions, sensory axons were unable to entrain stimulation frequencies above 50 Hz. There was significant variation in response declines between participants, suggesting that electrical stimulation therapies may require dose monitoring and tailoring for different individuals.

Fields of Study & Subjects

Transcranial Magnetic Stimulation Studies Neuroscience and Neural Engineering Muscle activation and electromyography studies

Publication details

Journal / source
Journal of Applied Physiology
Publisher
American Physiological Society
Volume
140
Issue
6
Pages
1614–1624
Publication date
13 May 2026
Language
EN