Model-based design of subthalamic nucleus neurons using hybrid optimization
Abstract
The optimized STN neuron model reproduces key features observed in experimental recordings, including spontaneous firing, action potential shape, hyperpolarization response, frequency-current relationship, and phase response to simulated synaptic input. In addition, the hybrid optimization strategy generated probability parameter distributions that not only improved the overall optimization results but also provided critical insights into how biophysical parameters influence firing characteristics.
Fields of Study & Subjects
Neurological disorders and treatments
Neural dynamics and brain function
stochastic dynamics and bifurcation
Publication details
- Journal / source
- Journal of Neurophysiology
- Volume
- 135
- Issue
- 3
- Pages
- 733–746
- Publication date
- 16 February 2026
- Language
- EN