LHX2 regulates biophysical properties of astrocytes in the postnatal mouse hippocampus
Abstract
Astrocytes play a vital role in regulating neural circuit homeostasis, yet the transcriptional mechanisms governing their electrophysiological properties remain underexplored. Here, we identify the LIM-homeodomain transcription factor LHX2 as a key regulator of intrinsic electrical properties of astrocytes in the hippocampus. We demonstrate that deletion of Lhx2 from postnatal astrocytes and their progenitors alters astrocytic membrane biophysics in adulthood, but this did not have noncell-autonomous effects on the intrinsic properties of CA1 pyramidal neurons.
Fields of Study & Subjects
Neuroscience and Neuropharmacology Research
Neurogenesis and neuroplasticity mechanisms
Neural dynamics and brain function
Publication details
- Journal / source
- Journal of Neurophysiology
- Volume
- 135
- Issue
- 2
- Pages
- 534–546
- Publication date
- 28 January 2026
- Language
- EN