Neuromodulatory strategies overcome multiple inevitable impairments of cerebral palsy

Journal of Neurophysiology 2026 Open access

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Authors: Susan D. Hastings, Hui Ping Zhong, Ken Kijima, Gonnella Cg, Gonnella Js, Darrin J. Lee, Charles Yu Liu, Yury P. Gerasimenko, V. Reggie Edgerton, Christopher A. Johnson
DOI: 10.1152/jn.00518.2025
Cited by: 1
References: 70

Abstract

This 2-year longitudinal case report extends beyond motor outcomes to examine systems-level changes in cerebral palsy (CP). Using combined qualitative and quantitative evidence, we show that pairing transcutaneous spinal neuromodulation with proprioceptive-derived intervention can engage activity-dependent neuroplasticity across multiple physiological domains. Coordinated improvements in motor, autonomic, and cognitive function, with distinct temporal dynamics and reversibility, suggest that enhancing proprioceptive signaling may modulate and improve distributed physiological networks and reveal clinically relevant targets for future study.

Fields of Study & Subjects

Cerebral Palsy and Movement Disorders Muscle activation and electromyography studies Transcranial Magnetic Stimulation Studies

Publication details

Journal / source
Journal of Neurophysiology
Publisher
American Physiological Society
Volume
136
Issue
2
Pages
445–458
Publication date
23 June 2026
Language
EN