Differential gene transcription following intravenous injection of air bubbles in rats with varying resistance to decompression sickness

Physiological Genomics 2026 Open access

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Authors: Jérémy Orsat, Emmanuel Gouin, Anthony Guernec, Costantino Balestra, Michaël Théron, Géraldine Leman, François Guerrero
DOI: 10.1152/physiolgenomics.00082.2026
Cited by: 1
References: 78

Abstract

This study suggests for the first time that DCS resistance may be associated with a better tolerance to VGE. This greater DCS resistance could be achieved through improved control of the procoagulant effects of bubbles via TFPI-dependent inhibitory mechanisms and an enhanced cellular stress response to VGE by HSP70, HSP27, and EGR-1. It also suggests that it may be possible to stratify the individual DCS risk based on the thromboinflammatory response to bubbles.

Fields of Study & Subjects

Cardiovascular and Diving-Related Complications Cancer Hypoxia and Metabolism Heme Oxygenase-1 and Carbon Monoxide

Publication details

Journal / source
Physiological Genomics
Publisher
American Physiological Society
Volume
58
Issue
7
Pages
304–318
Publication date
9 June 2026
Language
EN