Systems genomics reveals age- and sex-dependent metabolic dysregulation from Glo1 reduction in mice

Physiological Genomics 2026 Open access

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Authors: Ingrid Cely, Montgomery Blencowe, Le Shu, Graciel Diamante, In Sook Ahn, Guanglin Zhang, Jonnby S. LaGuardia, R. Henry Liu, Owen Briscoe, Zara Saleem, Susanna Wang, Richard C. Davis
+3 more Hongxiu Qi, Aldons J. Lusis, Xia Yang
DOI: 10.1152/physiolgenomics.00106.2025
Cited by: 1
References: 73

Abstract

This study reveals that partial deficiency of glyoxalase 1 (Glo1) leads to age- and sex-specific metabolic dysfunction in mice through transcriptional and regulatory changes independent of advanced glycation end products (AGEs). Transcriptomic profiling and integrative genomics identified female-biased transcription factors and genome-wide association study (GWAS)-linked metabolic genes as key mediators. These findings uncover novel, AGE-independent regulatory pathways linking Glo1 to metabolic disease risk and emphasize the importance of sex-specific analysis in metabolic genomics research.

Fields of Study & Subjects

Advanced Glycation End Products research Neutrophil Myeloperoxidase and Oxidative Mechanisms Immune cells in cancer

Publication details

Journal / source
Physiological Genomics
Publisher
American Physiological Society
Volume
58
Issue
3
Pages
125–143
Publication date
16 January 2026
Language
EN