Monitored food intake in early pregnancy modulates the maternal microbiome in the obese BPH/5 mouse model of superimposed preeclampsia
Abstract
Caloric restriction via monitored food intake in early pregnancy reshaped the maternal microbiome in obese BPH/5 mice, lowering fecal F/B ratios and enriching Bacteroides and Lactobacillus, while simultaneously reducing systemic acetic acid and increasing Proteobacteria in vaginal and oral sites. These findings reveal that diet-microbiome interactions in early gestation exert both beneficial and detrimental effects, underscoring the need for alternative interventions, potentially high-fiber, to support SCFA production and maternal-fetal health.
Fields of Study & Subjects
Pregnancy and preeclampsia studies
Gut microbiota and health
Birth
Development
and Health
Publication details
- Journal / source
- Physiological Genomics
- Publisher
- American Physiological Society
- Volume
- 58
- Issue
- 3
- Pages
- 144–151
- Publication date
- 24 January 2026
- Language
- EN