Changes in liver and lung antioxidant and mitochondrial biogenesis gene expression in decompression sickness resistant rats

Physiological Genomics 2026 Open access

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Authors: Emmanuel Dugrenot, Jérémy Orsat, Emmanuel Gouin, François Guerrero, Anthony Guernec
DOI: 10.1152/physiolgenomics.00218.2025
Cited by: 1
References: 52

Abstract

This study analyzed genes related to antioxidant defense and mitochondrial biogenesis in the lungs and liver of rats bred for resistance to decompression sickness (DCS). In resistant rats, no change was observed in lung gene expression, whereas both gene groups were downregulated in the liver ( P < 0.0083, Bonferroni correction), except Pgc1α. These findings, along with previous ones, suggest that hepatic mitochondrial function and reduced reactive oxygen species production may contribute to DCS resistance.

Fields of Study & Subjects

Cardiovascular and Diving-Related Complications Biological Research and Disease Studies Hemoglobin structure and function

Publication details

Journal / source
Physiological Genomics
Publisher
American Physiological Society
Volume
58
Issue
6
Pages
243–251
Publication date
23 April 2026
Language
EN