Multiomics alterations associated with tolerance and response to simulated progressive hemorrhage in healthy adult humans

Physiological Genomics 2026 Open access

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Authors: Burook Misganaw, Seid Muhie, Aarti Gautam, Stacy-Ann Miller, I. C. Bonilla Rosales, George I. Dimitrov, Bintu Sowe, Christopher P. Johnson, Shelly K. Roberts, Riley J. Regimbal, Chad C. Wiggins, Michael J. Joyner
+3 more Timothy B. Curry, V CONVERTINO, Rasha Hammamieh
DOI: 10.1152/physiolgenomics.00253.2025
Cited by: 2
References: 35

Abstract

This study investigated the first multiomics data for association with tolerance to central hypovolemia in humans. Analyzing gene expression, proteins, and genetic variants in individuals with high and low tolerance to simulated hemorrhage, the findings show that severe blood loss causes widespread transcriptional changes, including the activation of innate immune system pathways and inhibition of gas transport processes. This research can help identify molecular factors that influence individuals' tolerance levels for progressive blood loss.

Fields of Study & Subjects

Trauma Hemostasis Coagulopathy Resuscitation Sepsis Diagnosis and Treatment Hemoglobin structure and function

Publication details

Journal / source
Physiological Genomics
Publisher
American Physiological Society
Volume
58
Issue
2
Pages
102–114
Publication date
7 January 2026
Language
EN