Epigenetic signatures and genetic variants associated with muscle strength in postmenopausal women: potential bone muscle cross talk via BMP1 mechanisms

Physiological Genomics 2026

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Authors: Guilherme da Silva Rodrigues, Natália Yumi Noronha, Jonas Benjamim, Andressa Crystine da Silva Sobrinho, Ivo Vieira de Sousa Neto, Chanachai Sae-Lee, Pitaksin Chitta, Takuji Kawamura, Fernando Barbosa Júnior, Carla Barbosa Nonino, Lígia Moriguchi Watanabe, Carlos Roberto Bueno Junior
DOI: 10.1152/physiolgenomics.00254.2025
Cited by: 2
References: 66

Abstract

This study integrates genome-wide genotyping, DNA methylation, and transcriptomic validation to reveal genetic and epigenetic determinants of muscle strength in postmenopausal women. We identify novel SNPs, a predictive polygenic risk score, and higher BMP1 epigenetic scores linked to greater muscle strength and bone remodeling pathways. These multiomics insights provide potential biomarkers for musculoskeletal aging and targets for strategies to preserve strength and skeletal health in older women.

Fields of Study & Subjects

TGF-β signaling in diseases Genetics and Physical Performance Bone health and osteoporosis research

Publication details

Journal / source
Physiological Genomics
Publisher
American Physiological Society
Volume
58
Issue
3
Pages
152–169
Publication date
3 February 2026
Language
EN