Systemic and proximal tubule specific knockout of Arhgef11 and impact on hypertension and kidney injury

Physiological Genomics 2026 Open access

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Authors: Wenjie Wu, Lavanya Challagundla, Andrew R. Milner, Michael R. Garrett, Ashley C. Johnson
DOI: 10.1152/physiolgenomics.00299.2025
Cited by: 1
References: 54

Abstract

, specifically within the context of experimental hypertension (AngII or DOCA), plays a role in regulating blood pressure at the systemic or kidney-specific level. A slight protective effect on blood pressure and kidney injury for DOCA knockout models was observed, replicating the rat knockout. However, the large effect in the rat model is likely explained by the highly permissive genetic background of the Dahl SS model.

Fields of Study & Subjects

Parathyroid Disorders and Treatments Ion Transport and Channel Regulation Sodium Intake and Health

Publication details

Journal / source
Physiological Genomics
Publisher
American Physiological Society
Volume
58
Issue
7
Pages
273–291
Publication date
1 June 2026
Language
EN