Effects of CMV on T and NK Cells; With Emphasis on Immunometabolism

BioMed Research International 2026 Open access

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Authors: Haideh Namdari, Mohsen Keshavarz, Maryam Hosseini, Farzad Parvizpour, Asrin Emami, Elahe Izadi, Milad Shahbazi Asl, Mehdi Shahgolzari, Farhad Rezaei
DOI: 10.1155/bmri/7838997
Cited by: 1
References: 108

Abstract

CMV is masterful at manipulating stress responses and conducting them in a way that yields beneficial outcomes. CMV always causes metabolic changes in the infected cells. However, nutritional status affects the pattern of events following CMV infection. Oxidative phosphorylation (OXPHOS) and glycolysis are two vital pathways for energy generation in mammalian cells, which differ in terms of ATP production and location. Understanding metabolic alterations required for CMV infection may lead to the design of novel therapeutic methods based on targeted inhibition of these cellular metabolic pathways. This review explores how CMV mimics, exploits, or interferes with the host cell, with emphasis on immunometabolism, and how, in doing so, it may evade immune responses.

Fields of Study & Subjects

Cytomegalovirus and herpesvirus research Immune Cell Function and Interaction Immune cells in cancer

Publication details

Journal / source
BioMed Research International
Publisher
Wiley
Volume
2026
Issue
1
Pages
e7838997–e7838997
Publication date
1 January 2026
Language
EN