Research Progress of Interstitial Lung Disease Based on Single‐Cell Sequencing Technology

Canadian Respiratory Journal 2026 Open access

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Authors: Shujing Li, Shujing Li, tao zhou, 张继英, Li Zhang, Bin Li, Bin Li, Jine Dai, Rui Yu, Yi Li, Shaoying Li, Shaoying Li
DOI: 10.1155/carj/8863968
Cited by: 2
References: 49

Abstract

Interstitial lung disease (ILD) refers to a collection of respiratory conditions characterized by inflammation of the lung parenchyma, alveolar irritation, and fibrosis of the interstitial tissue. Traditional research methods are often unable to completely reveal the complex mechanism of ILD occurrence and development. However, advancements in single-cell sequencing technology in recent years have opened up a novel avenue for investigating ILD. This review summarizes recent single-cell-sequencing advances in the major interstitial lung diseases-idiopathic pulmonary fibrosis (IPF), pneumoconiosis, and connective tissue disease-associated ILD (CTD-ILD)-and outlines future research priorities.

Fields of Study & Subjects

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Single-cell and spatial transcriptomics IL-33 ST2 and ILC Pathways

Publication details

Journal / source
Canadian Respiratory Journal
Publisher
Wiley
Volume
2026
Issue
1
Pages
8863968–8863968
Publication date
1 January 2026
Language
EN