“White Cord Syndrome”: A Reperfusion Injury Following Laminectomy and Spinal Decompression Surgery—A Case Report and Literature Review

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Authors: Iran Chanideh, Amirmohammad Khodaei, Masoud Ghadiri, Zeinab Shakibaee Fard, Mohammad Mehdi Falahi Tabar, Arian Yavari, Sepehr Niktash
Cited by: 1
References: 24

Abstract

White cord syndrome (WCS) is a rare but serious postoperative complication characterized by new neurological deficits and hyperintense signal changes on T2-weighted magnetic resonance imaging (MRI) following spinal decompression surgery. Since it was first described by Chin et al. in 2013, WCS has been attributed to reperfusion injury resulting from sudden restoration of blood flow to chronically ischemic spinal cord tissue. Oxidative stress, microvascular thrombosis, and impaired autoregulation have been proposed as contributing factors. We report the case of a 61-year-old Iranian man with a history of cervical canal stenosis who developed quadriparesis and paresthesia following posterior decompression surgery. Postoperative MRI revealed hyperintense signals consistent with WCS. High-dose methylprednisolone was administered immediately, leading to partial neurological recovery during hospitalization. This case highlights the importance of early recognition and aggressive management of WCS to improve functional outcomes. Raising awareness of this syndrome among spine surgeons is essential for timely diagnosis and management.

Fields of Study & Subjects

Cervical and Thoracic Myelopathy Intraoperative Neuromonitoring and Anesthetic Effects Spinal Cord Injury Research

Publication details

Journal / source
Case Reports in Medicine
Publisher
Wiley
Volume
2026
Issue
1
Pages
5539165–5539165
Publication date
1 January 2026
Language
EN