Methotrexate‐Associated Lymphoproliferative Disorders Characterized by a T‐Cell Phenotype With Lung and Psoas Involvement: A Case Report

Case Reports in Medicine 2026 Open access

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Authors: Katsunori Arai, Hirokazu Tokuyasu, Yuriko Sueda, Hiromitsu Sakai, Hirara Watase, Mikako Yoshioka, Yoshiki Naritomi, Chika Esumi, Akira Yamasaki
DOI: 10.1155/carm/7668419
Cited by: 1
References: 13

Abstract

Methotrexate (MTX) can cause MTX-associated lymphoproliferative disorders (MTX-LPDs) characterized by a T-cell phenotype. Herein, we report an extremely rare case of MTX-LPD with peripheral T-cell lymphoma (PTCL) phenotype and lung and skeletal muscle involvement. A 66-year-old man who had received MTX for 8 years for rheumatoid arthritis was admitted for right groin pain. A computed tomography scan revealed masses in the right middle lobe and right psoas muscle and multiple nodules in both lung fields. Pathological and immunohistochemical examinations of a lung nodule and psoas muscle tumor revealed PTCL. Remission was achieved soon after discontinuing MTX.

Fields of Study & Subjects

Viral-associated cancers and disorders Lymphoma Diagnosis and Treatment Cutaneous lymphoproliferative disorders research

Publication details

Journal / source
Case Reports in Medicine
Publisher
Wiley
Volume
2026
Issue
1
Pages
7668419–7668419
Publication date
1 January 2026
Language
EN