A CLIP on the Ear: Spitz Melanocytoma Harbouring a CLIP2-BRAF Gene Fusion

Case Reports in Dermatological Medicine 2026 Open access

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Authors: Karwan A. Moutasim, Mohammed Atweh, Jeffery M. Theaker
DOI: 10.1155/crdm/1460562
Cited by: 0
References: 4

Abstract

Spitzoid lesions represent one of the most challenging areas in melanocytic pathology. Many such lesions are characterised by key gene alterations including ALK, ROS and NTRK fusions. BRAF mutations are generally considered incompatible with the diagnosis of Spitz tumours. Here, we present the case of a spitzoid melanocytoma harbouring a rare BRAF gene fusion. A brief overview of the literature is also touched upon.

Fields of Study & Subjects

Cutaneous Melanoma Detection and Management Melanoma and MAPK Pathways Neurofibromatosis and Schwannoma Cases

Publication details

Journal / source
Case Reports in Dermatological Medicine
Volume
2026
Issue
1
Pages
1460562–1460562
Publication date
1 January 2026
Language
EN