Vanishing Bile Duct Syndrome as an Uncommon Hepatic Paraneoplastic Syndrome in Hodgkin’s Lymphoma

Case Reports in Hepatology 2026 Open access

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Authors: Natasha Salman, Diana Sittirat Petchpailin, Amanda Seemann, Apurva A. Modi, Rohan Gupta, Shovendra Gautam
DOI: 10.1155/crhe/4166844
Cited by: 1
References: 8

Abstract

Vanishing bile duct syndrome (VBDS) is a rare form of liver injury caused by ischemia, drug reactions, autoimmune diseases, infections, or malignancy. VBDS involves the progressive disappearance of intrahepatic bile ducts, causing cholestasis and biliary cirrhosis, with high mortality if untreated. VBDS can also present as a paraneoplastic syndrome in Hodgkin's lymphoma (HL). A 53-year-old female presented with jaundice, pruritus, diarrhea, and elevated liver function tests (LFTs). A liver biopsy demonstrated cholestasis with mild ductopenia, and imaging revealed enlarged para-aortic lymph nodes. A bone marrow biopsy confirmed HL, and chemotherapy normalized symptoms and LFTs.

Fields of Study & Subjects

Liver Diseases and Immunity Liver Disease and Transplantation Organ Transplantation Techniques and Outcomes

Publication details

Journal / source
Case Reports in Hepatology
Publisher
Wiley
Volume
2026
Issue
1
Pages
4166844–4166844
Publication date
1 January 2026
Language
EN