Culture‐Negative Infective Endocarditis Presenting With Cardio‐Hepatorenal Syndrome in a 21‐Year‐Old Patient: A Case Report of Diagnostic Workup and Management

Infective endocarditis (IE) imposes a challenge in clinical practice, often demanding rapid and precise identification of the causative agent to guide tailored therapeutic interventions. However, a subset of cases presents an elusive diagnostic dilemma with culture-negative results, thereby complicating the management strategy. This case report sheds light on a particularly rare instance of culture-negative IE in a 21-year-old previously healthy male who presented with dyspnea and jaundice, emphasizing the scarcity of such cases in the existing medical literature. Through a detailed examination of clinical manifestations, diagnostic modalities, and treatment outcomes, we aim to contribute valuable insights into the nuanced aspects of culture-negative IE. Furthermore, this report underscores the imperative need for clinicians to maintain a high index of suspicion for IE, even in the absence of positive cultures, to ensure timely and appropriate management for improved patient prognosis.