Three Malagasy Cases of Severe Bone Complications Revealing Primary Hyperparathyroidism

Case Reports in Endocrinology 2026 Open access

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Authors: Zo L. Andrianadison, Lalao Nomenjanahary Rakotonirina, Oliva Henintsoa Rakotonirainy, Mamonjisoa Olivier Andrianiaina, Rakotomahefa N Mbola, Fahafahantsoa Rapelanoro Rabenja
DOI: 10.1155/crie/9622659
Cited by: 0
References: 31

Abstract

Primary hyperparathyroidism (PHPT) is a metabolic disorder characterized by hypercalcemia with elevated or unsuppressed parathyroid hormone (PTH). It is rare in children but common in adults, particularly in women around the age of 50. In 85% of cases, PHPT is asymptomatic and is diagnosed following hypercalcemia and elevated PTH levels during routine examinations. PHPT occurring before the age of 25 and the normocalcemic phenotype are unusual situations that may delay diagnosis. These nonclassical forms expose patients to severe bone complications that can cause disability. Our objective is to report three clinical cases of PHPT revealed by catastrophic skeletal deformities and pathological fractures.

Fields of Study & Subjects

Parathyroid Disorders and Treatments Bone health and osteoporosis research Thyroid and Parathyroid Surgery

Publication details

Journal / source
Case Reports in Endocrinology
Volume
2026
Issue
1
Pages
9622659–9622659
Publication date
1 January 2026
Language
EN