Animal Models and Treatment of Pulmonary Fibrosis: Pharmacogenetic and Nonpharmacogenetic

Pulmonary fibrosis is a significant lung injury caused by multiple factors that profoundly affect the human quality of life. Currently, various animal models are used to understand the aetiology of pulmonary fibrosis and develop treatments. However, only pharmacogenetic models of pulmonary fibrosis have been discussed, and there have been no reviews of drug treatments. This study reviewed research articles as of August 2023 in major literature databases outlining different techniques for animal modelling of pulmonary fibrosis, including pharmacogenetic and nonpharmacogenetic approaches. Additionally, treatment approaches from both Western and traditional Chinese medicine are discussed. Study results show that along with commonly recognised medications such as pirfenidone and nintedanib, many traditional Chinese remedies and natural products, such as resveratrol and Qingfei Paidu, also offer preventative and therapeutic effects against pulmonary fibrosis.